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Are Weekly Injections for Weight Loss Safe

September 12, 2025

A young man is smiling at home, standing in front of the camera, wearing jeans and showing weight loss results from weekly weight loss injections.

A weekly injection for weight loss has become a popular option for people struggling to lose weight. These weight loss medicines work by changing how your body handles hunger and food. But many people wonder if these shots are actually safe to use.

The answer is yes, when used properly under medical supervision. The Food and Drug Administration (FDA) has approved several weight loss injections that you take once per week. These include semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound). Both medications have gone through extensive testing to prove they work and are safe for most people.

Let us explore weekly weight loss injections and what research shows about their safety.

How Do Weekly Weight Loss Injections Work

Weight loss injections that are FDA approved work by mimicking hormones in your body that control hunger and blood sugar. These hormones are called GLP-1 receptor agonists. When you take these shots, they slow down how fast food leaves your stomach. This makes you feel full longer after eating.

These medications also affect your brain’s hunger signals. They help reduce cravings and make you feel satisfied with smaller portions. This combination makes it easier to eat less and lose weight without feeling constantly hungry.

Semaglutide (Ozempic, Wegovy)

Semaglutide was first approved for treating type 2 diabetes. Doctors noticed that patients taking it also lost significant amounts of weight. The FDA then approved higher doses specifically for weight loss under the brand name Wegovy.

This medication works by activating GLP-1 receptors in your body. These receptors help control blood sugar and slow digestion. The result is reduced appetite and better blood sugar control. Many patients find this weekly injection for weight loss easier to manage than daily medications.

Tirzepatide (Mounjaro, Zepbound)

Tirzepatide is newer than semaglutide but works in a similar way. It targets both GLP-1 and GIP receptors. This dual action may lead to even greater weight loss for some people.

The FDA approved tirzepatide for diabetes treatment first. Later, it received approval for weight loss treatment. Studies show it can be very effective for helping people lose substantial amounts of weight.

What Research Shows About Safety

Multiple large studies have examined the safety of a weekly injection for weight loss. These studies followed thousands of people for months or years to track any side effects.

A study published in the New England Journal of Medicine followed 1,961 adults taking semaglutide for weight loss. The research lasted 68 weeks and found that people lost an average of 14.9% of their body weight. Most side effects were mild and related to digestion, such as nausea and diarrhea. The study showed that FDA-approved weight loss injections can be both effective and safe when properly monitored.

Another study published in the New England Journal of Medicine examined tirzepatide in 2,539 adults with obesity. Participants took the medication for 72 weeks. Those on the highest dose lost an average of 20.9% of their body weight. The most common side effects were also digestive issues that usually improved over time.

Common Side Effects

Most people who use weight loss injections that are FDA approved experience some side effects, especially when starting treatment. The good news is that most side effects are mild and temporary.

The most common side effects include:

  • Nausea
  • Vomiting
  • Diarrhea
  • Stomach pain
  • Constipation
  • Headache
  • Fatigue

These side effects usually happen during the first few weeks of treatment. Your doctor will typically start you on a low dose and gradually increase it. This helps your body adjust to the medication and reduces side effects.

Serious Side Effects to Watch For

While weekly injections for weight loss are generally safe, there are some serious side effects to be aware of. These are rare but require immediate medical attention.

Serious side effects can include:

  • Pancreatitis (inflammation of the pancreas)
  • Gallbladder problems
  • Kidney problems
  • Severe allergic reactions
  • Thyroid tumors (seen in animal studies)

Your doctor will monitor you for these issues during treatment. They will also review your medical history to make sure these medications are safe for you specifically.

Who Should Not Use These Medications

Not everyone is a good candidate for the weekly injection for weight loss. Certain medical conditions and situations make these medications unsafe.

You should not use these medications if you have:

  • Personal or family history of medullary thyroid cancer.
  • Multiple endocrine neoplasia syndrome type 2.
  • Severe kidney disease.
  • Active gallbladder disease.
  • History of pancreatitis.
  • Pregnancy or breastfeeding.

Your healthcare provider will carefully review your medical history before prescribing any weight loss injections that are FDA-approved. They will also discuss any medications you currently take to avoid dangerous interactions.

Working With Your Healthcare Provider

The safety of the weekly injection for weight loss depends heavily on proper medical supervision. Your doctor will monitor you throughout treatment to ensure the medication is working safely and effectively.

Regular check-ups allow your healthcare provider to:

  • Monitor your weight loss progress.
  • Check for side effects.
  • Adjust your dosage if needed.
  • Review your overall health.

Never start or stop these medications without talking to your doctor first. They can help you determine if these treatments are right for your specific situation.

Weekly Injections for Weight Loss in Dallas, TX

Ready to explore whether weight loss injections might be right for you? Contact North Dallas Wellness Center. Our highly trained and experienced Dr. David Fein will work with you to determine the best course of treatment for your weight loss goals. Our clinic offers a variety of options, including the weekly injection for weight loss, as well as customized meal plans and exercise regimens to support your journey towards a healthier lifestyle.

In addition to medical supervision and personalized treatment plans, we also provide ongoing support and guidance throughout your weight loss journey.

To learn more about weekly injections for weight loss, contact our staff today at (214) 696-3885 or use our appointment request form to schedule a consultation. We look forward to serving you!

Filed Under: Medical Weight Loss Tagged With: exercise, Medications, Semaglutide, Tirzepatide, weekly injection for weight loss, Weekly Injections for Weight Loss in Dallas, weight loss injections fda approved, weight-loss goals

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